brd0539价格-k8凯发

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cas no. :

mce 国际站：

产品活性：brd0539 是一种可渗透细胞的，无毒的 crispr-cas9 抑制剂。在体外 dna 裂解试验中，brd0539 可抑制化脓性链球菌 cas9 (spcas9)，ic₅₀ 为 22 μm。

研究领域：

作用靶点：

in vitro: brd0539 dose-dependently blocks the formation of the dna-bound state in a dose-dependent fashion. brd0539 impairs the perturbation induced by the 4pam dna.
brd0539 does not interfere with the spcas9:grna interaction.
brd0539 is able to inhibit spcas9 in the egfp-disruption assay, brd0539 is unable to inhibit fncpf1, a structurally different crispr-associated nuclease, in the same assay, further highlighting the specificity of brd0539.

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